Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model

Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model

Epilepsy is a comorbidity associated with Alzheimer's disease (AD), often starting many years earlier than memory decline. Investigating this association in the early pre-symptomatic stages of AD can unveil new mechanisms of the pathology as well as guide the use of antiepileptic drugs to preve...

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Bibliographic Details
Main Authors: Emanuela Rizzello, Domenico Pimpinella, Annabella Pignataro, Giulia Titta, Elisabetta Merenda, Michela Saviana, Giovanni Francesco Porcheddu, Chiara Paolantoni, Francesca Malerba, Corinna Giorgi, Giulia Curia, Silvia Middei, Cristina Marchetti
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
hippocampus
Epilepsy
Neuronal excitability
Contextual fear conditioning
Lamotrigine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001201

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http://www.sciencedirect.com/science/article/pii/S0969996123001201

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