Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria

Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria

ABSTRACT Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has been identified as the major determinant for ART resistance in the background of other mutations, which include the...

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Bibliographic Details
Main Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
P. falciparum
artemisinin
resistance
UPR
PI3P
autophagy
Online Access:https://journals.asm.org/doi/10.1128/mbio.00630-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00630-22

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