Single-Cell RNA Sequencing and Quantitative Proteomics Analysis Elucidate Marker Genes and Molecular Mechanisms in Hypoplastic Left Heart Patients With Heart Failure

Single-Cell RNA Sequencing and Quantitative Proteomics Analysis Elucidate Marker Genes and Molecular Mechanisms in Hypoplastic Left Heart Patients With Heart Failure

ObjectiveTo probe markers and molecular mechanisms of the hypoplastic left heart (HLH) by single-cell RNA sequencing (scRNA-seq) and quantitative proteomics analysis.MethodsFollowing data preprocessing, scRNA-seq data of pluripotent stem cell (iPSC)-derived cardiomyocytes from one HLH patient and on...

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Bibliographic Details
Main Authors: Li Ma, Na Zhou, Rongjun Zou, Wanting Shi, Yuanyuan Luo, Na Du, Jing Zhong, Xiaodong Zhao, Xinxin Chen, Huimin Xia, Yueheng Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoplastic left heart
single-cell RNA sequencing
quantitative proteomics analysis
cardiac development
hub genes
heart failure
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.617853/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.617853/full

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