Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect.

C-type natriuretic peptide (CNP) is a pivotal enhancer of endochondral bone growth and is expected to be a therapeutic reagent for impaired skeletal growth. Although we showed that CNP stimulates bone growth as a local regulator in the growth plate via the autocrine/paracrine system, CNP is abundant...

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Bibliografski detalji
Glavni autori: Yohei Ueda, Keisho Hirota, Ichiro Yamauchi, Takuro Hakata, Takafumi Yamashita, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Format: Članak
Jezik:English
Izdano: Public Library of Science (PLoS) 2020-01-01
Serija:PLoS ONE
Online pristup:https://doi.org/10.1371/journal.pone.0240023