ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.

ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.

ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis) are marine derived compounds that have antitumor activity. ET-743 and PM00104 exposure over sustained periods of treatment will result in the development of drug resistance, but the mechanisms which lead to resistance are not yet understood.Human...

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Bibliographic Details
Main Authors: Zhenfeng Duan, Edwin Choy, David Harmon, Cao Yang, Keinosuke Ryu, Joseph Schwab, Henry Mankin, Francis J Hornicek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2734182?pdf=render

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http://europepmc.org/articles/PMC2734182?pdf=render

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