One-step microwave enhanced synthesis, biological evaluation, and molecular modeling investigations of donepezil analogs as acetylcholinesterase inhibitors

One-step microwave enhanced synthesis, biological evaluation, and molecular modeling investigations of donepezil analogs as acetylcholinesterase inhibitors

Acetylcholinesterase (AChE) is an important enzyme that hydrolyzes the neurotransmitter acetylcholine. Inhibiting AChE represents one of the therapeutic strategies for treating the symptoms of Alzheimer’s disease (AD). To date, only several AD drugs have been approved by the U.S. Food and Drug Admin...

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Bibliographic Details
Main Authors: Tiffany Azusada, Elijah Baybay, Jasmine Chi, Paulina Dole, Nancy Gonzalez, Eliu Jaramillo, Thu Nguyen, Ashley Pivaral, Gala Rodriguez, Jacob Zavala, Heyam Zayed, Alex Gaspar, Sam Andino, Khoa Nguyen, Sebastian Pintea, Henry Nguyen, Paula K. Hudson, Stevan Pecic
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Enzyme inhibition
Structure-activity relationship studies
Microwave-assisted synthesis
Molecular modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623004654

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http://www.sciencedirect.com/science/article/pii/S2211715623004654

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