One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones

One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones

A one-pot fluorination and organocatalytic Robinson annulation sequence has been developed for asymmetric synthesis of 6-fluoroyclohex-2-en-1-ones and 4,6-difluorocyclohex-2-en-1-ones. The reactions promoted by cinchona alkaloid amine afforded products bearing two or three stereocenters in good to e...

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Bibliographic Details
Main Authors: Xin Huang, Weizhao Zhao, Xiaofeng Zhang, Miao Liu, Stanley N. S. Vasconcelos, Wei Zhang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
organocatalysis
fluorination
α-fluoro-β-keto ester
Michael addition
Robinson annulation
cyclohexenone
Online Access:http://www.mdpi.com/1420-3049/23/9/2251

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http://www.mdpi.com/1420-3049/23/9/2251

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