Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis

Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis

Abstract Extracellular vesicles (EVs) can be produced from red blood cells (RBCs) on a large scale and used to deliver therapeutic payloads efficiently. However, not much is known about the native biological properties of RBCEVs. Here, we demonstrate that RBCEVs are primarily taken up by macrophages...

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Bibliographic Details
Main Authors: Thach Tuan Pham, Anh Hong Le, Cong Phi Dang, Suet Yen Chong, Dang Vinh Do, Boya Peng, Migara Kavishka Jayasinghe, Hong Boon Ong, Dong Van Hoang, Roma Anne Louise, Yuin‐Han Loh, Han Wei Hou, Jiong‐Wei Wang, Minh TN Le
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Extracellular Vesicles
Subjects:
atherosclerosis
endocytosis
extracellular vesicles
foam cells
haemoglobin
mheme
Online Access:https://doi.org/10.1002/jev2.12354

Internet

https://doi.org/10.1002/jev2.12354

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