SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling

SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling

Introduction: A SeDeM expert tool-driven I-optimal mixture design has been used to develop a directly compressible multiparticulate based extended release minitablets for gastro-retentive drug delivery systems using loxoprofen sodium as a model drug.Methods: Powder blends were subjected to stress dr...

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Bibliographic Details
Main Authors: Rauf-ur-Rehman, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Talha Saleem, Faaiza Qazi, Momina Zarish Khan, Asma Irshad, Lubna Bashir, Shazia Naz, Muhammad Farooq, Zafar Alam Mahmood
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
multiparticulate drug delivery system
SeDeM expert tool
loxoprofen Na
in silico PBPK
extended release minitablets
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1066018/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1066018/full

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