Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse

Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse

Existing marker-based methods of minimal residual disease (MRD) determination in neuroblastoma do not effectively enrich for the circulating disease cell population. Given the relative size differential of neuroblastoma tumor cells over normal hematogenous cells, we hypothesized that cell size-based...

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Bibliographic Details
Main Authors: Amos H. P. Loh, Clara Angelina, Meng Kang Wong, Sheng Hui Tan, Sarvesh A. Sukhatme, Trifanny Yeo, Su Bin Lim, York Tien Lee, Shui Yen Soh, Wing Leung, Kenneth T. E. Chang, Yong Wei Chua, Syed M. F. Alkaff, Tony K. H. Lim, Chwee Teck Lim, Zhi Xiong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
circulating tumor cells
neuroblastoma
minimal residual disease
microfluidic
bone marrow metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.939460/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.939460/full

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