Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with <em>DMD</em> Deletion

Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with <em>DMD</em> Deletion

Whole-genome doubling is the second most frequent genomic event, after <i>TP53</i> alterations, in advanced solid tumors and is associated with poor prognosis. Tetraploidization step will lead to aneuploidy and chromosomic rearrangements. The mechanism leading to tetraploid cells is impo...

Full description

Bibliographic Details
Main Authors: Candice Merle, Noémie Thébault, Sophie LeGuellec, Jessica Baud, Gaëlle Pérot, Tom Lesluyes, Lucile Delespaul, Lydia Lartigue, Frédéric Chibon
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
cell fusion
genomic instability
sarcoma
dystrophin
Online Access:https://www.mdpi.com/2072-6694/12/5/1281

Internet

https://www.mdpi.com/2072-6694/12/5/1281

Similar Items