The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain

The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain

Francisella tularensis is a highly infectious bacterial pathogen that causes the potentially fatal disease tularemia. The Live Vaccine Strain (LVS) of F. tularensis subsp. holarctica, while no longer licensed as a vaccine, is used as a model organism for identifying correlates of immunity and bacter...

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Bibliographic Details
Main Authors: Joshua R. Fletcher, Deborah D. Crane, Tara D. Wehrly, Craig A. Martens, Catharine M. Bosio, Bradley D. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
Francisella tularensis
iron acquisition mechanism
microbial pathogenesis
inflammatory mechanisms
virulence mechanisms
intracellular pathogen
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00607/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00607/full

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