An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

Abstract Background Triple-negative breast cancer (TNBC) remains a difficult breast cancer subtype to treat as it exhibits a particularly aggressive behavior. The dysregulation of distinct signaling pathways underlies this aggressive behavior, with an overactivation of MAP kinase interacting kinases...

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Bibliographic Details
Main Authors: Vladimir Mulens-Arias, Yadileiny Portilla, Sonia Pérez-Yagüe, Raquel Ferreras-Martín, M. Elena Martín, Victor M. González, Domingo F. Barber
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cancer Nanotechnology
Subjects:
Aptamer
MNK1
Polyethyleneimine-coated iron oxide nanoparticles
Antitumor effect
Online Access:https://doi.org/10.1186/s12645-023-00204-8

Internet

https://doi.org/10.1186/s12645-023-00204-8

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