Co-evolution based machine-learning for predicting functional interactions between human genes

With the rise in number of eukaryotic species being fully sequenced, large scale phylogenetic profiling can give insights on gene function, Here, the authors describe a machine-learning approach that integrates co-evolution across eukaryotic clades to predict gene function and functional interaction...

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Bibliographic Details
Main Authors: Doron Stupp, Elad Sharon, Idit Bloch, Marinka Zitnik, Or Zuk, Yuval Tabach
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26792-w