The specific mitochondrial unfolded protein response in fast- and slow-twitch muscles of high-fat diet-induced insulin-resistant rats

The specific mitochondrial unfolded protein response in fast- and slow-twitch muscles of high-fat diet-induced insulin-resistant rats

IntroductionSkeletal muscle insulin resistance (IR) plays an important role in the pathogenesis of type 2 diabetes mellitus. Skeletal muscle is a heterogeneous tissue composed of different muscle fiber types that contribute distinctly to IR development. Glucose transport shows more protection in slo...

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Bibliographic Details
Main Authors: Can Li, Nan Li, Ziyi Zhang, Yu Song, Jialin Li, Zhe Wang, Hai Bo, Yong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
insulin resistance
skeletal muscle fiber type
UPRmt
MOTS-c
epigenetic modification
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1127524/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1127524/full

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