Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease
Abstract Background The clinical features of Alzheimer’s disease (AD) vary substantially depending on whether the onset of cognitive deficits is early or late. The amount and distribution patterns of tau pathology are thought to play a key role in the clinical characteristics of AD, which spreads th...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-022-01061-0 |
| _version_ | 1798037318593937408 |
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| author | Wha Jin Lee Hanna Cho Min Seok Baek Han-Kyeol Kim Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo Joon-Kyung Seong |
| author_facet | Wha Jin Lee Hanna Cho Min Seok Baek Han-Kyeol Kim Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo Joon-Kyung Seong |
| author_sort | Wha Jin Lee |
| collection | DOAJ |
| description | Abstract Background The clinical features of Alzheimer’s disease (AD) vary substantially depending on whether the onset of cognitive deficits is early or late. The amount and distribution patterns of tau pathology are thought to play a key role in the clinical characteristics of AD, which spreads throughout the large-scale brain network. Here, we describe the differences between tau-spreading processes in early- and late-onset symptomatic individuals on the AD spectrum. Methods We divided 74 cognitively unimpaired (CU) and 68 cognitively impaired (CI) patients receiving 18F-flortaucipir positron emission tomography scans into two groups by age and age at onset. Members of each group were arranged in a pseudo-longitudinal order based on baseline tau pathology severity, and potential interregional tau-spreading pathways were defined following the order using longitudinal tau uptake. We detected a multilayer community structure through consecutive tau-spreading networks to identify spatio-temporal changes in the propagation hubs. Results In each group, ordered tau-spreading networks revealed the stage-dependent dynamics of tau propagation, supporting distinct tau accumulation patterns. In the young CU/early-onset CI group, tau appears to spread through a combination of three independent communities with partially overlapped territories, whose specific driving regions were the basal temporal regions, left medial and lateral temporal regions, and left parietal regions. For the old CU/late-onset CI group, however, continuation of major communities occurs in line with the appearance of hub regions in the order of bilateral entorhinal cortices, parahippocampal and fusiform gyri, and lateral temporal regions. Conclusion Longitudinal tau propagation depicts distinct spreading pathways of the early- and late-onset AD spectrum characterized by the specific location and appearance period of several hub regions that dominantly provide tau. |
| first_indexed | 2024-04-11T21:24:56Z |
| format | Article |
| id | doaj.art-5a11152b76334561bb10cd4a5268d04b |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-11T21:24:56Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-5a11152b76334561bb10cd4a5268d04b2022-12-22T04:02:28ZengBMCAlzheimer’s Research & Therapy1758-91932022-09-0114111310.1186/s13195-022-01061-0Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer diseaseWha Jin Lee0Hanna Cho1Min Seok Baek2Han-Kyeol Kim3Jae Hoon Lee4Young Hoon Ryu5Chul Hyoung Lyoo6Joon-Kyung Seong7School of Biomedical Engineering, Korea UniversityDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Wonju Severance Christian Hospital, Yonsei University Wonju College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineSchool of Biomedical Engineering, Korea UniversityAbstract Background The clinical features of Alzheimer’s disease (AD) vary substantially depending on whether the onset of cognitive deficits is early or late. The amount and distribution patterns of tau pathology are thought to play a key role in the clinical characteristics of AD, which spreads throughout the large-scale brain network. Here, we describe the differences between tau-spreading processes in early- and late-onset symptomatic individuals on the AD spectrum. Methods We divided 74 cognitively unimpaired (CU) and 68 cognitively impaired (CI) patients receiving 18F-flortaucipir positron emission tomography scans into two groups by age and age at onset. Members of each group were arranged in a pseudo-longitudinal order based on baseline tau pathology severity, and potential interregional tau-spreading pathways were defined following the order using longitudinal tau uptake. We detected a multilayer community structure through consecutive tau-spreading networks to identify spatio-temporal changes in the propagation hubs. Results In each group, ordered tau-spreading networks revealed the stage-dependent dynamics of tau propagation, supporting distinct tau accumulation patterns. In the young CU/early-onset CI group, tau appears to spread through a combination of three independent communities with partially overlapped territories, whose specific driving regions were the basal temporal regions, left medial and lateral temporal regions, and left parietal regions. For the old CU/late-onset CI group, however, continuation of major communities occurs in line with the appearance of hub regions in the order of bilateral entorhinal cortices, parahippocampal and fusiform gyri, and lateral temporal regions. Conclusion Longitudinal tau propagation depicts distinct spreading pathways of the early- and late-onset AD spectrum characterized by the specific location and appearance period of several hub regions that dominantly provide tau.https://doi.org/10.1186/s13195-022-01061-0Alzheimer’s diseaseTauAmyloidPositron emission tomographyNetwork community |
| spellingShingle | Wha Jin Lee Hanna Cho Min Seok Baek Han-Kyeol Kim Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo Joon-Kyung Seong Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease Alzheimer’s Research & Therapy Alzheimer’s disease Tau Amyloid Positron emission tomography Network community |
| title | Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease |
| title_full | Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease |
| title_fullStr | Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease |
| title_full_unstemmed | Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease |
| title_short | Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease |
| title_sort | dynamic network model reveals distinct tau spreading patterns in early and late onset alzheimer disease |
| topic | Alzheimer’s disease Tau Amyloid Positron emission tomography Network community |
| url | https://doi.org/10.1186/s13195-022-01061-0 |
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