The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity

The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity

Nucleoporins (NUPs) are cellular effectors of human immunodeficiency virus-1 (HIV-1) replication that support nucleocytoplasmic trafficking of viral components. However, these also non-canonically function as positive effectors, promoting proviral DNA integration into the host genome and viral gene...

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Bibliographic Details
Main Authors: Kumaraswami Chintala, Sriram Yandrapally, Warisha Faiz, Chhaya Rani Kispotta, Satarupa Sarkar, Krishnaveni Mishra, Sharmistha Banerjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
nuclear pore complexes
NUP98
HIV-1 LTR
transcription
viral gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330738/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330738/full

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