Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus

Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus

Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region. Three-dimensional (3D) bioprinted scaffolds loaded with live cells and bio...

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Bibliographic Details
Main Authors: Xin Sun, Zhenjiang Ma, Xue Zhao, Wenjie Jin, Chenyu Zhang, Jie Ma, Lei Qiang, Wenhao Wang, Qian Deng, Han Yang, Jinzhong Zhao, Qianqian Liang, Xiaojun Zhou, Tao Li, Jinwu Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-03-01
Series:Bioactive Materials
Subjects:
Three-dimensional bioprinting
Diabetic bone defect
Bone morphogenic protein-4
Macrophage polarization
Bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20302036

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http://www.sciencedirect.com/science/article/pii/S2452199X20302036

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