Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence

Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence

Lung cancer is by far the leading cause of cancer death worldwide, and 85% of patients are diagnosed with non-small cell lung cancer (NSCLC), which is still very difficult to treat. Skp2 functions as an oncogene that participates in processes of many cancers. Here, we report a novel Skp2 inhibitor A...

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Bibliographic Details
Main Authors: Jinyi Liu, Xiangjin Zheng, Wan Li, Liwen Ren, Sha Li, Yihui Yang, Hong Yang, Binbin Ge, Guanhua Du, Jianyou Shi, Jinhua Wang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Pharmacological Research
Subjects:
AAA-237
Skp2
Cell cycle
Apoptosis
Senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822002043

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http://www.sciencedirect.com/science/article/pii/S1043661822002043

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