Dietary Cholest-4-en-3-one, a Cholesterol Metabolite of Gut Microbiota, Alleviates Hyperlipidemia, Hepatic Cholesterol Accumulation, and Hyperinsulinemia in Obese, Diabetic <i>db/db</i> Mice

Dietary Cholest-4-en-3-one, a Cholesterol Metabolite of Gut Microbiota, Alleviates Hyperlipidemia, Hepatic Cholesterol Accumulation, and Hyperinsulinemia in Obese, Diabetic <i>db/db</i> Mice

Previous studies have shown that dietary cholest-4-en-3-one (4-cholestenone, 4-STN) exerts anti-obesity and lipid-lowering effects in mice. However, its underlying mechanisms are not fully understood. In the present study, we evaluated whether 4-STN supplementation would protect obese diabetic <i...

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Bibliographic Details
Main Authors: Mina Higuchi, Mai Okumura, Sarasa Mitsuta, Bungo Shirouchi
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Metabolites
Subjects:
cholest-4-en-3-one
4-cholestenone
hyperlipidemia
hyperinsulinemia
<i>db/db</i> mice
Online Access:https://www.mdpi.com/2218-1989/14/6/321

Internet

https://www.mdpi.com/2218-1989/14/6/321

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