INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation

INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation

The evasion of the Interferon response has important implications in Zika virus (ZIKV) disease. Mutations in ZIKV viral protein NS4B, associated with modulation of the interferon (IFN) system, have been linked to increased pathogenicity in animal models. In this study, we unravel ZIKV NS4B as antago...

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Bibliographic Details
Main Authors: Elisa Fanunza, Nicole Grandi, Marina Quartu, Fabrizio Carletti, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito, Enzo Tramontano
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
Zika virus
interferon
interferon evasion
NS4B
STAT1
STAT2
Online Access:https://www.mdpi.com/1999-4915/13/12/2448

Internet

https://www.mdpi.com/1999-4915/13/12/2448

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