Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress

Summary: Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood. Here, we show that mitochondria form spatially defin...

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Bibliographic Details
Main Authors: Lea Bertgen, Jan-Eric Bökenkamp, Tim Schneckmann, Christian Koch, Markus Räschle, Zuzana Storchová, Johannes M. Herrmann
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003462