A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages

A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages

Abstract Because of the rapid mutation and high airborne transmission of SARS‐CoV‐2, a universal vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a mosaic receptor‐binding domain (RBD) nanoparticle (NP) vaccine is developed, which induces more RBD‐targete...

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Bibliographic Details
Main Authors: Xiantao Zhang, Shijian Wu, Jie Liu, Ran Chen, Yongli Zhang, Yingtong Lin, Zhihui Xi, Jieyi Deng, Zeyu Pu, Chaofeng Liang, Jinzhu Feng, Rong Li, Keming Lin, Mo Zhou, Yingying Liu, Xu Zhang, Bingfeng Liu, Yiwen Zhang, Xin He, Hui Zhang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
broad neutralizing antibody
mosaic nanoparticle vaccine
mucosal immune responses
SARS‐CoV‐2
universal vaccines
Online Access:https://doi.org/10.1002/advs.202301034

Internet

https://doi.org/10.1002/advs.202301034

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