Similar programmed death ligand 1 (PD-L1) expression profile in patients with mild COPD and lung cancer

Similar programmed death ligand 1 (PD-L1) expression profile in patients with mild COPD and lung cancer

Abstract Programmed Death Ligand 1 (PD-L1) is crucial in regulating the immunological tolerance in non-small cell lung cancer (NSCLC). Alveolar macrophage (AM)-derived PD-L1 binds to its receptor, PD-1, on surveilling lymphocytes, leading to lymphocyte exhaustion. Increased PD-L1 expression is assoc...

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Bibliographic Details
Main Authors: F. Polverino, D. Mirra, C. X. Yang, R. Esposito, G. Spaziano, J. Rojas-Quintero, M. Sgambato, E. Piegari, A. Cozzolino, E. Cione, L. Gallelli, A. Capuozzo, C. Santoriello, L. Berrino, J. P. de- Torres, T. L. Hackett, M. Polverino, B. D’Agostino
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26650-9

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https://doi.org/10.1038/s41598-022-26650-9

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