GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to derive from epithelial failure, particularly that...

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Bibliographic Details
Main Authors: Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
dyskeratosis congenita
type II alveolar epithelial cells
pulmonary fibrosis
Wnt
Online Access:https://elifesciences.org/articles/64430

Internet

https://elifesciences.org/articles/64430

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