MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spectrum. Some of these mutations, such as the N279K...

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Bibliographic Details
Main Authors: Lisanne Korn, Anna M. Speicher, Christina B. Schroeter, Lukas Gola, Thilo Kaehne, Alexander Engler, Paul Disse, Juncal Fernández-Orth, Júlia Csatári, Michael Naumann, Guiscard Seebohm, Sven G. Meuth, Hans R. Schöler, Heinz Wiendl, Stjepana Kovac, Matthias Pawlowski
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
MAPT mutation
Cell death
Mitochondria
ROS
FTLD
Forward programming
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200369X

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http://www.sciencedirect.com/science/article/pii/S221323172200369X

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