Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the pathogenesis of various inflammatory and autoimmune diseases. This context-dependent effect from a cytokine is due to two distinctive forms of signaling: <i>cis</i&...

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Bibliographic Details
Main Authors: Dhanu Gupta, Sara Orehek, Janne Turunen, Liz O’Donovan, Michael J. Gait, Samir El-Andaloussi, Matthew J. A. Wood
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/18/2285