A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation [version 2; peer review: 2 approved]

Background: Low-complexity regions (LCRs) on proteins have attracted increasing attention recently due to their role in the assembly of membraneless organelles or granules by liquid-liquid phase separation. Several examples of such granules have been shown to sequester RNA and proteins in an inactiv...

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Bibliographic Details
Main Authors: Mathieu Cayla, Keith R. Matthews, Alasdair C. Ivens
Format: Article
Language:English
Published: Wellcome 2020-11-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/5-219/v2