Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway

Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway

Objectives: IL1β enhances proliferation of synovial mesenchymal stem/stromal cells (synMSCs) although they don't express its receptor, IL1R1/CD121a, on the cell surface. This study was aimed to elucidate the underlying mechanisms of IL1β-mediated growth promotion. Methods: Human synMSCs were is...

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Bibliographic Details
Main Authors: Guo Tang, Yoshinori Asou, Etsuko Matsumura, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Keiichiro Komori, Ichiro Sekiya, Yoich Ezura, Kunikazu Tsuji
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Heliyon
Subjects:
Cell growth
Cytokine expression
IL1β
IL1R1/ CD121a
Synovial MSCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022007642

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http://www.sciencedirect.com/science/article/pii/S2405844022007642

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