Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease

Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease

Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in male smokers with a prevalence below 1%. This exploratory study aims to shed light on cellular mechanisms involved in PAA progression. Sixteen human PAA and eight non-aneurysmatic popliteal artery samples, pa...

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Bibliographic Details
Main Authors: Jessica Pauli, Tessa Reisenauer, Greg Winski, Nadja Sachs, Ekaterina Chernogubova, Hannah Freytag, Christoph Otto, Christian Reeps, Hans-Henning Eckstein, Claus-Jürgen Scholz, Lars Maegdefessel, Albert Busch
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
popliteal artery aneurysm
apolipoprotein E
vascular smooth muscle cell
phenotype switch
proliferation
Online Access:https://www.mdpi.com/2218-273X/13/7/1074

Internet

https://www.mdpi.com/2218-273X/13/7/1074

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