Potent Antimicrobial and Antibiofilm Activities of Feleucin-K3 Analogs Modified by α-(4-Pentenyl)-Ala against Multidrug-Resistant Bacteria

Potent Antimicrobial and Antibiofilm Activities of Feleucin-K3 Analogs Modified by α-(4-Pentenyl)-Ala against Multidrug-Resistant Bacteria

The dramatic increase in antimicrobial resistance (AMR) highlights an urgent need to develop new antimicrobial therapies. Thus, antimicrobial peptides (AMPs) have emerged as promising novel antibiotic alternatives. Feleucin-K3 is an amphiphilic α-helical nonapeptide that has powerful antimicrobial a...

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Bibliographic Details
Main Authors: Xiaomin Guo, Tiantian Yan, Jing Rao, Xin Yue, Xiong Pei, Jiahui Deng, Wangsheng Sun, Wenle Yang, Bangzhi Zhang, Junqiu Xie
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
antimicrobial peptide analogs
unnatural hydrophobic amino acid
α-(4-pentenyl)-Ala
antimicrobial activity
antibiofilm activity
Online Access:https://www.mdpi.com/2218-273X/11/5/761

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https://www.mdpi.com/2218-273X/11/5/761

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