Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis

Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis

Pulmonary fibrosis is characterized by stiffening of the extracellular matrix. Fibroblasts migrate in the direction of greater stiffness, a phenomenon termed durotaxis. The mechanically guided fibroblast migration could be a crucial step in the progression of lung fibrosis. In this study, we found p...

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Bibliographic Details
Main Authors: Ting Guo, Chun-sun Jiang, Shan-Zhong Yang, Yi Zhu, Chao He, A. Brent Carter, Veena B. Antony, Hong Peng, Yong Zhou
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
Cell biology
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.157348

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