A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of a glutamine repeat in the protein ataxin-3, which is deposited as intracellular aggregates in affected brain regions. Despite the controversial role of ataxin-3 amyloid structures in SCA3 pathology, the identification of molecules wi...

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Bibliographic Details
Main Authors: Francisco Figueiredo, Mónica Lopes-Marques, Bruno Almeida, Nena Matscheko, Pedro M. Martins, Alexandra Silva, Sandra Macedo-Ribeiro
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
thioflavin-T
polyglutamine expansion
reproducibility
ubiquitin
self-association rates
equilibrium dissociation constant
Online Access:https://www.mdpi.com/2073-4409/11/12/1969

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https://www.mdpi.com/2073-4409/11/12/1969

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