Optogenetic control of GGGGCC repeat-containing RNA phase transition

Optogenetic control of GGGGCC repeat-containing RNA phase transition

The GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is a major cause of both hereditary amyotrophic lateral sclerosis and familial frontotemporal dementia. Recent studies have shown that G4C2 hexanucleotide repeat-containing RNA transcripts ((G4C2)n RNA) could go through liquid-liq...

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Bibliographic Details
Main Authors: Xiong Li, Shengyi Lu, Boxun Lu, Xiaoli Sun
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-11-01
Series:Fundamental Research
Subjects:
RNA aggregates
Liquid-liquid phase separation
Optogenetics
Chromosome 9 open reading frame 72 (C9ORF72)
Amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667325822003612

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http://www.sciencedirect.com/science/article/pii/S2667325822003612

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