Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis

Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis

Abstract Background Paraquat (PQ) is a widely used and highly toxic herbicide that poses a significant risk to human health. The main consequence of PQ poisoning is pulmonary fibrosis, which can result in respiratory failure and potentially death. Our research aims to uncover a crucial mechanism in...

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Bibliographic Details
Main Authors: Min Zhang, Xiang Xue, Zhenshuai Lou, Yanhong Lin, Qian Li, Changbao Huang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Paraquat
Exosome
SIRT1
miR-217-5p
Pulmonary fibrosis
Online Access:https://doi.org/10.1186/s12967-024-05094-x

Internet

https://doi.org/10.1186/s12967-024-05094-x

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