Comprehensive In Silico Functional Prediction Analysis of CDKL5 by Single Amino Acid Substitution in the Catalytic Domain

Comprehensive In Silico Functional Prediction Analysis of CDKL5 by Single Amino Acid Substitution in the Catalytic Domain

Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine protein kinase whose pathological mutations cause CDKL5 deficiency disorder. Most missense mutations are concentrated in the catalytic domain. Therefore, anticipating whether mutations in this region affect CDKL5 function is informative fo...

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Bibliographic Details
Main Authors: Yuri Yoshimura, Atsushi Morii, Yuuki Fujino, Marina Nagase, Arisa Kitano, Shiho Ueno, Kyoka Takeuchi, Riko Yamashita, Tetsuya Inazu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
CDKL5
in silico prediction analysis
PolyPhen-2
PROVEAN
SIFT
single amino acid substitutions
Online Access:https://www.mdpi.com/1422-0067/23/20/12281

Internet

https://www.mdpi.com/1422-0067/23/20/12281

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