Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

Tongmai Yangxin (TMYX) is a complex compound of the Traditional Chinese Medicine (TCM) used to treat several cardiac rhythm disorders; however, no information regarding its mechanism of action is available. In this study we provide a detailed characterization of the effects of TMYX on the electrical...

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Bibliographic Details
Main Authors: Chiara Piantoni, Manuel Paina, David Molla, Sheng Liu, Giorgia Bertoli, Hongmei Jiang, Yanyan Wang, Yi Wang, Dario DiFrancesco, Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
pacemaker current
sinoatrial node
TMYX
pure bradycardic agents
cAMP antagonism
HCN channels
Online Access:https://elifesciences.org/articles/75119

Internet

https://elifesciences.org/articles/75119

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