Demonstration of Binding Induced Structural Plasticity in a SH2 Domain

Demonstration of Binding Induced Structural Plasticity in a SH2 Domain

SH2 domains are common protein interaction domains able to recognize short aminoacidic sequences presenting a phosphorylated tyrosine (pY). In spite of their fundamental importance for cell physiology there is a lack of information about the mechanism by which these domains recognize and bind their...

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Bibliographic Details
Main Authors: Lorenzo Visconti, Angelo Toto, James A. Jarvis, Francesca Troilo, Francesca Malagrinò, Alfonso De Simone, Stefano Gianni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
allosteric network
skinetics
mutagenesis
peptide binding
NMR
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00089/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00089/full

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