Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer

Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer

Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DOcollagen I (a bone matrix protein) and, for comparison, DO-collagen IV, by living human prostate carcinoma cells in vitro. Both collagens were degraded, this degradation was reduced by inhibitors of matrix...

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Bibliographic Details
Main Authors: Izabela Podgorski, Bruce E. Linebaugh, Mansoureh Sameni, Christopher Jedeszko, Sunita Bhagat, Michael L. Cher, Bonnie F. Sloane
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cathepsin B
bone microenvironment
prostate cancer
osteolysis
tumor-stromal interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800223

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http://www.sciencedirect.com/science/article/pii/S1476558605800223

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