Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydiatrachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01

Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydiatrachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01

The development of a vaccine against genital chlamydia in women is advancing, and the evaluation of in situ immune responses following vaccination and challenge infections is crucial for development of a safe and protective vaccine. This study employs the sexually mature minipig model to characteriz...

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Bibliographic Details
Main Authors: Karin Erneholm, Emma Lorenzen, Sarah Bøje, Anja Weinreich Olsen, Gregers Jungersen, Henrik E. Jensen, Joseph P. Cassidy, Peter Andersen, Jørgen S. Agerholm, Frank Follmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
porcine
chlamydia
pathology
histology
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00197/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00197/full

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