Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages

Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages

Aims: Pellino1 (Peli1) has been reported to regulate various inflammatory diseases. This study aims to explore the role of Peli1 in the occurrence and development of osteoarthritis (OA), so as to find new targets for the treatment of OA. Methods: After inhibiting Peli1 expression in chondrocytes wit...

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Bibliographic Details
Main Authors: Haokun Mo, Zhenggang Wang, Zhiyi He, Junlai Wan, Rui Lu, Chenwen Wang, Anmin Chen, Peng Cheng
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-02-01
Series:Bone & Joint Research
Subjects:
peli1
chondrocyte
macrophage
polarization
toll-like receptor
osteoarthritis (oa)
chondrocytes
macrophages
apoptosis
inflammation
synovitis
rna
destruction of cartilage
interleukin
inflammatory diseases
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.122.BJR-2022-0214.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.122.BJR-2022-0214.R1

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