Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

Abstract Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process h...

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Bibliographic Details
Main Authors: Patriciu Achimas-Cadariu, Paul Kubelac, Alexandru Irimie, Ioana Berindan-Neagoe, Frank Rühli
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Ovarian Research
Subjects:
Online Access:https://doi.org/10.1186/s13048-022-01004-1