A novel pipeline for prioritizing cancer type‐specific therapeutic vulnerabilities using DepMap identifies PAK2 as a target in head and neck squamous cell carcinomas

A novel pipeline for prioritizing cancer type‐specific therapeutic vulnerabilities using DepMap identifies PAK2 as a target in head and neck squamous cell carcinomas

There is limited guidance on exploiting the genome‐wide loss‐of‐function CRISPR screens in cancer Dependency Map (DepMap) to identify new targets for individual cancer types. This study integrated multiple tools to filter these data in order to seek new therapeutic targets specific to head and neck...

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Bibliographic Details
Main Authors: Malay K. Sannigrahi, Austin C. Cao, Pavithra Rajagopalan, Lova Sun, Robert M. Brody, Lovely Raghav, Phyllis A. Gimotty, Devraj Basu
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Molecular Oncology
Subjects:
CRISPR
DepMap
head and neck squamous cell carcinoma
PAK2
targeted therapy
wild type p53
Online Access:https://doi.org/10.1002/1878-0261.13558

Internet

https://doi.org/10.1002/1878-0261.13558

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