Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito vectors, is safe in rats, and pharmacokinetic-phar...
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Bibliographic Details
| Main Authors: |
Laura E. de Vries,
Patrick A. M. Jansen,
Catalina Barcelo,
Justin Munro,
Julie M. J. Verhoef,
Charisse Flerida A. Pasaje,
Kelly Rubiano,
Josefine Striepen,
Nada Abla,
Luuk Berning,
Judith M. Bolscher,
Claudia Demarta-Gatsi,
Rob W. M. Henderson,
Tonnie Huijs,
Karin M. J. Koolen,
Patrick K. Tumwebaze,
Tomas Yeo,
Anna C. C. Aguiar,
Iñigo Angulo-Barturen,
Alisje Churchyard,
Jake Baum,
Benigno Crespo Fernández,
Aline Fuchs,
Francisco-Javier Gamo,
Rafael V. C. Guido,
María Belén Jiménez-Diaz,
Dhelio B. Pereira,
Rosemary Rochford,
Camille Roesch,
Laura M. Sanz,
Graham Trevitt,
Benoit Witkowski,
Sergio Wittlin,
Roland A. Cooper,
Philip J. Rosenthal,
Robert W. Sauerwein,
Joost Schalkwijk,
Pedro H. H. Hermkens,
Roger V. Bonnert,
Brice Campo,
David A. Fidock,
Manuel Llinás,
Jacquin C. Niles,
Taco W. A. Kooij,
Koen J. Dechering |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-29688-5
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