17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage

17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage

Background/Aims: The risk of heart disease is higher in males than in females. However, this advantage of females declines with increasing age, presumably a consequence of decreased estrogen secretion and malfunctioning of the estrogen receptor. We previously demonstrated that 17β-estradiol (E2) pre...

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Bibliographic Details
Main Authors: Dennis Jine-Yuan Hsieh, Wei-Wen Kuo, Yi-Ping Lai, Marthandam Asokan Shibu, Chia-Yao Shen, Peiying Pai, Yu-Lan Yeh, Jing-Ying Lin, Vijaya Padma Viswanadha, Chih-Yang Huang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
17β-estradiol
Estrogen receptor β
Hypoxia
Autophagy
Cardiac apoptosis
Online Access:http://www.karger.com/Article/FullText/374070

Internet

http://www.karger.com/Article/FullText/374070

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