Clinical associations and genetic interactions of oncogenic BRAF alleles
BRAF is a serine/threonine-specific protein kinase that regulates the MAPK/ERK signaling pathway, and mutations in the BRAF gene are considered oncogenic drivers in diverse types of cancer. Based on the signaling mechanism, oncogenic BRAF mutations can be assigned to three different classes: class 1...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2022-10-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/14126.pdf |