Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways
In schizophrenia, a single latent trait underlies psychosis, hostility, excitation, mannerism, negative (PHEMN) symptoms, formal thought disorders (FTD) and psychomotor retardation (PMR). Schizophrenia is accompanied by a breakdown of gut and blood-brain-barrier (BBB) pathways, increased tryptophan...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2019-11-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2019-0023 |
| _version_ | 1819135598517026816 |
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| author | Maes Michael Vojdani Aristo Geffard Michel Moreira Estefania G. Barbosa Decio S. Michelin Ana Paula Semeão Laura de Oliveira Sirivichayakul Sunee Kanchanatawan Buranee |
| author_facet | Maes Michael Vojdani Aristo Geffard Michel Moreira Estefania G. Barbosa Decio S. Michelin Ana Paula Semeão Laura de Oliveira Sirivichayakul Sunee Kanchanatawan Buranee |
| author_sort | Maes Michael |
| collection | DOAJ |
| description | In schizophrenia, a single latent trait underlies psychosis, hostility, excitation, mannerism, negative (PHEMN) symptoms, formal thought disorders (FTD) and psychomotor retardation (PMR). Schizophrenia is accompanied by a breakdown of gut and blood-brain-barrier (BBB) pathways, increased tryptophan catabolite (TRYCAT) levels, bacterial translocation, and lowered natural IgM and paraoxonase (PON)1 activity. |
| first_indexed | 2024-12-22T10:21:38Z |
| format | Article |
| id | doaj.art-5a5d24d570624a0aac77f0527519d6ca |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-22T10:21:38Z |
| publishDate | 2019-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-5a5d24d570624a0aac77f0527519d6ca2022-12-21T18:29:37ZengDe GruyterBiomolecular Concepts1868-50211868-503X2019-11-0110120922510.1515/bmc-2019-0023bmc-2019-0023Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathwaysMaes Michael0Vojdani Aristo1Geffard Michel2Moreira Estefania G.3Barbosa Decio S.4Michelin Ana Paula5Semeão Laura de Oliveira6Sirivichayakul Sunee7Kanchanatawan Buranee8Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandImmunosciences Lab., Inc, Los Angeles, CA, USA, Cyrex Labs, LLC, Phoenix, AZ, USAIDRPHT, Research Department, Talence, FranceHealth Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, BrazilHealth Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, BrazilHealth Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, BrazilHealth Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, BrazilDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandIn schizophrenia, a single latent trait underlies psychosis, hostility, excitation, mannerism, negative (PHEMN) symptoms, formal thought disorders (FTD) and psychomotor retardation (PMR). Schizophrenia is accompanied by a breakdown of gut and blood-brain-barrier (BBB) pathways, increased tryptophan catabolite (TRYCAT) levels, bacterial translocation, and lowered natural IgM and paraoxonase (PON)1 activity.https://doi.org/10.1515/bmc-2019-0023schizophreniainflammationoxidative stressneuro-immunegut bacteriaantioxidants |
| spellingShingle | Maes Michael Vojdani Aristo Geffard Michel Moreira Estefania G. Barbosa Decio S. Michelin Ana Paula Semeão Laura de Oliveira Sirivichayakul Sunee Kanchanatawan Buranee Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways Biomolecular Concepts schizophrenia inflammation oxidative stress neuro-immune gut bacteria antioxidants |
| title | Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways |
| title_full | Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways |
| title_fullStr | Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways |
| title_full_unstemmed | Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways |
| title_short | Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways |
| title_sort | schizophrenia phenomenology comprises a bifactorial general severity and a single group factor which are differently associated with neurotoxic immune and immune regulatory pathways |
| topic | schizophrenia inflammation oxidative stress neuro-immune gut bacteria antioxidants |
| url | https://doi.org/10.1515/bmc-2019-0023 |
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