Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis

Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis

Abstract Background Pathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. Despite notable advancements in the development of anti-angiogenic medications that target vascular endothelial growth factor (VEGF) and its receptors (VEGFRs...

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Bibliographic Details
Main Authors: Jun-Song Ren, Wen Bai, Jing-Juan Ding, Hui-Min Ge, Su-Yu Wang, Xi Chen, Qin Jiang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Tumor angiogenesis
Ocular pathologic neovascularization
AFAP1L1
Hypoxia
HIF-1α
Vascular tip cell
Online Access:https://doi.org/10.1186/s12967-023-04503-x

Internet

https://doi.org/10.1186/s12967-023-04503-x

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