Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA

Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA

Abstract Background As circulating DNA (cirDNA) is mainly detected as mononucleosome-associated circulating DNA (mono-N cirDNA) in blood, apoptosis has until now been considered as the main source of cirDNA. The mechanism of cirDNA release into the circulation, however, is still not fully understood...

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Bibliographic Details
Main Authors: Ekaterina Pisareva, Lucia Mihalovičová, Brice Pastor, Andrei Kudriavtsev, Alexia Mirandola, Thibault Mazard, Stephanie Badiou, Ulrich Maus, Lena Ostermann, Julia Weinmann-Menke, Elmo W. I. Neuberger, Perikles Simon, Alain R. Thierry
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Genome Medicine
Subjects:
Circulating DNA
Elastase
Myeloperoxidase
Neutrophil
NET
Nucleosome
Online Access:https://doi.org/10.1186/s13073-022-01125-8

Internet

https://doi.org/10.1186/s13073-022-01125-8

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