Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates

Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates

Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached to the PBD A-ring C8 position. A convergent approach was successfully adopted for the synthesis of a novel C8-linked pyrrolo(2,1-<i>c&...

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Bibliographic Details
Main Authors: Lindsay Ferguson, Sanjib Bhakta, Keith R. Fox, Geoff Wells, Federico Brucoli
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
c8-linked pyrrolobenzodiazepine (pbd) conjugates
dna minor groove binding agents
dnase i footprinting
adenosine nucleoside
heterodimeric hybrids
high-throughput spot-culture growth inhibition assay
anti-mycobacterial compounds
Online Access:https://www.mdpi.com/1420-3049/25/5/1243

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https://www.mdpi.com/1420-3049/25/5/1243

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